CHOLINESTERASE ACTIVITY OF ARCHICEREBELLAR MOSSY FIBRE APPARATUSES

Photoregulation of cholinesterase activity

Abszrucz: The study of the functioning of cholinesterases and in particular the identification of the clearance of enzymatic products from the active site, is undertaken by two different photoregulatory methodologies. A mechanism-based photo-inactivation of the cholinesterases is proposed to map this route of clearance. The use of radiolabeled probes will permit to identify the modified amino a...

Action potential initiation and propagation in hippocampal mossy fibre axons.

Dentate gyrus granule cells transmit action potentials (APs) along their unmyelinated mossy fibre axons to the CA3 region. Although the initiation and propagation of APs are fundamental steps during neural computation, little is known about the site of AP initiation and the speed of propagation in mossy fibre axons. To address these questions, we performed simultaneous somatic and axonal whole-...

Lateral thinking: CaMKII uncouples kainate receptors from mossy fibre synapses.

Alteration of the efficacy of excitatory synaptic transmission between neurons is a critical element in the processes of learning, memory, and behaviour. Despite decades of research aimed at elucidating basic cellular mechanisms underlying synaptic plasticity, new pathways and permutations continue to be discovered. Carta et al (2013) now show that activation of the calcium/calmodulin dependent...

In vitro cholinesterase inhibitory activity of Areca catechu L.

Background and objectives: Alzheimer’s disease (AD) is characterized as the most prevalent age related neurodegenerative disease along with cognitive impairment in elderly people. Most of therapeutic treatments for AD have dedicated to the inhibition of cholinesterase (ChEs) to increase the level of acetylcholine (ACh) in the cholinergic synaptic cleft. Acetylcholinesterase (AC...

Determination of cholinesterase activity in human blood.